EzWeb/FAST: Reporting on a Successful Mashup-based Solution for Developing and Deploying Composite Applications in the Upcoming Web of Services

Service oriented architectures (SOAs) based on Web Services have attracted a great interest and IT investments during the last years, principally in the context of business-to-business integration within corporate intranets. However, they are nowadays evolving to break through enterprise boundaries, in a revolutionary attempt to make the approach pervasive, leading to what we call a user-centric SOA, i.e. a SOA conceived as a Web of Services made up of compositional resources that empowers end-users to ubiquitously exploit these resources by collaboratively remixing them. In this paper we explore the architectural basis, technologies, frameworks and tools considered necessary to face this novel vision of SOA. We also present the rationale behind EzWeb/FAST: an undergoing EU funded project whose first outcomes could serve as a preliminary proof of concep

EzWeb/FAST: Reporting on a Successful Mashup-based Solution for Developing and Deploying Composite Applications in the Upcoming "Ubiquitous SOA"

Service oriented architectures (SOAs) based on Web services have attracted a great interest and IT investments during the last years, principally in the context of business-to-business integration within corporate Intranets. However, they are nowadays evolving to break through enterprise boundaries, in a revolutionary attempt to make the approach pervasive, leading to what we call the ubiquitous SOA, i.e. a SOA conceived as a Web of services made up of compositional resources that empowers end-users to ubiquitously exploit these resources by collaboratively remixing them. In this paper we explore the architectural basis, technologies, frameworks and tools considered necessary to face this novel vision of SOA. We also present the rationale behind EzWeb/FAST: an undergoing EU funded project whose first outcomes could serve as a preliminary proof of concep

A user-centric approach for developing and deploying service front-ends in the future internet of services

Service-Oriented Architectures (SOAs) based on web services have attracted a great deal of interest and Internet Technology (IT) investment over the last few years, principally in the context of business-to-business integration within corporate intranets. However, they are now evolving and breaking through enterprise boundaries in a revolutionary attempt to make the approach pervasive. This is leading to what we call a user-centric SOA. A user-centric SOA is an SOA conceived as an internet of services made up of compositional resources empowering end users to collaboratively remix and ubiquitously exploit these resources. In this paper we explore the architectural basis, technologies, frameworks and tools considered necessary to tackle this novel vision of SOA. We also present the rationale behind Ez Web/FAST, an ongoing EU-funded project whose first outcomes could serve as a preliminary proof of concept

Enabling Innovation across the Enterprise through Mashup-oriented Collaboration Environments

Nowadays enterprise collaboration is becoming essential for valuable innovation and competitive advantage. This collaboration must be brought a step forward from technical collaboration till collective smart exploitation of global intelligence. The Internet of Future is expected to be composed of a mesh of interoperable Web Services accessed from all over the Web. This approach has not yet caught on since a global user-service interaction is still an open issue. This paper states our vision with regard to the next generation front-end web technology that will enable integrated access to services, contents and things in the Future Internet. This approach will enable the massive deployment of services over Internet in a user-centric fashion. Having this in mind, the rationale behind EzWeb, a reference architecture and implementation of an open Enterprise 2.0 Collaboration Platform that empower its users to co-produce and share instant applications is presente

Enhancing User-Service Interaction Through a Global User-Centric Approach to SOA

Considered as enablers of seamless application-to- application integration both within company boundaries and on a global scale, Web Services-based SOAs have traditionally focused on automating service-to-service collaboration. However, they have never featured a "face " to human users. This gap between human users and services still prevents enterprises from realizing how innovations at the SOA front-end help to make people more productive. And, ultimately, it hinders the emergence of a real Web of Services driven by a global, user-centric SOA. In this paper, we revisit the notion of SOA and analyze its major shortcomings with regard to the emergence of a Web of Services enhancing user-service interaction and increased service usability. We then elaborate on novel, currently emerging technologies that facilitate the establishment of the global mesh of interoperable user-centric services. A novel platform architecture is presented that builds on all the key technical enablers

The Morfeo Open Source Community: Building Technologies of the Future Web through Open Innovation

Nowadays enterprise collaboration is becoming essential for valuable innovation and competitive advantage. This collaboration has to be brought a step forward from technical collaboration till collective smart exploitation of global intelligence. Morfeo Open Source Community implements it as an open innovation schema of collaboration among SME’s, universities, research centres, public administration and major corporations. Its disruptive contribution to the state of the art is to manage the collaboration licensing the shared technology as open, with an OSI accepted license. The main results of this innovation model are the development of SOA open software standards, the increase of OSS quality, the creation of an OSS services provider ecosystem, with an important impact in the local economical development and the dissemination of the R&D&i activities among a broader set of organizations. Now Morfeo, with established relationship in Spain and EU, is involved defining new cooperation schemas in Ibero-America. The aim is to define a network of Morfeo Office in several countries to coordinate the global communit

Preliminary study on the use of near infrared hyperspectral imaging for quantitation and localisation of total glucosinolates in freeze-dried broccoli

peer-reviewedThe use of hyperspectral imaging to (a) quantify and (b) localise total glucosinolates in florets of a single broccoli species has been examined. Two different spectral regions (vis–NIR and NIR), a number of spectral pre-treatments and different mask development strategies were studied to develop the quantitative models. These models were then applied to freeze-dried slices of broccoli to identify regions within individual florets which were rich in glucosinolates. The procedure demonstrates potential for the quantitative screening and localisation of total glucosinolates in broccoli using the 950–1650 nm wavelength range. These compounds were mainly located in the external part of florets.Universidad de SevillaJ.M. Hernández-Hierro thanks the Spanish MICINN for the Juan de la Cierva contract (JCI-2011-09201) and Universidad de Sevilla for the mobility Grant (Universidad de Sevilla Research Plan). Spanish MICINN Project AGL2011-30254-C02 and Junta de Andalucia PGC Project AGR 6331

The Networked Forge: New Environments for Libre Software Development

Libre (free, open source) software forges (sites hosting the development infrastructure for a collection of projects) have been stable in architecture, services and concept since they become popular during the late 1990s. During this time several problems that cannot be solved without dramatic design changes have become evident. To overcome them, we propose a new concept, the “networked forge”, focused on addressing the core characteristics of libre software development and the needs of developers. The key of this proposal is to re-engineer forges as a net of distributed components which can be composed and configured according to the needs of users, using a combination of web 2.0, semantic web and mashup technologies. This approach is flexible enough to accommodate different development processes, while at the same time interoperates with current facilitie

Accelerated amyloid angiopathy and related vascular alterations in a mixed murine model of Alzheimer´s disease and type two diabetes

Amyloid; Multiphoton microscopy; PrediabetesAmiloide; Microscòpia multifotònica; PrediabetisAmiloide; Microscopía multifotónica; PrediabetesBackground While aging is the main risk factor for Alzheimer´s disease (AD), emerging evidence suggests that metabolic alterations such as type 2 diabetes (T2D) are also major contributors. Indeed, several studies have described a close relationship between AD and T2D with clinical evidence showing that both diseases coexist. A hallmark pathological event in AD is amyloid-β (Aβ) deposition in the brain as either amyloid plaques or around leptomeningeal and cortical arterioles, thus constituting cerebral amyloid angiopathy (CAA). CAA is observed in 85–95% of autopsy cases with AD and it contributes to AD pathology by limiting perivascular drainage of Aβ. Methods To further explore these alterations when AD and T2D coexist, we have used in vivo multiphoton microscopy to analyze over time the Aβ deposition in the form of plaques and CAA in a relevant model of AD (APPswe/PS1dE9) combined with T2D (db/db). We have simultaneously assessed the effects of high-fat diet-induced prediabetes in AD mice. Since both plaques and CAA are implicated in oxidative-stress mediated vascular damage in the brain, as well as in the activation of matrix metalloproteinases (MMP), we have also analyzed oxidative stress by Amplex Red oxidation, MMP activity by DQ™ Gelatin, and vascular functionality. Results We found that prediabetes accelerates amyloid plaque and CAA deposition, suggesting that initial metabolic alterations may directly affect AD pathology. T2D significantly affects vascular pathology and CAA deposition, which is increased in AD-T2D mice, suggesting that T2D favors vascular accumulation of Aβ. Moreover, T2D synergistically contributes to increase CAA mediated oxidative stress and MMP activation, affecting red blood cell velocity. Conclusions Our data support the cross-talk between metabolic disease and Aβ deposition that affects vascular integrity, ultimately contributing to AD pathology and related functional changes in the brain microvasculature.University of Cadiz Predoctoral Fellowship (CHB). This study is part of the current project (RECOGNISED; Clinical Trials gov registration no. NCT04281186) funded by the European Commission (H2020 programme-GA 847749) focusing on common mechanisms in the pathogenesis of diabetic retinopathy, brain pathology and cognitive impairment, with special interest in the neurovascular unit, in the T2D population. Agencia Estatal de Investigacion. Ministerio de Ciencia e Innovacion. Programa Estatal de Generacion de Conocimiento y Fortalecimiento Cientifico y Tecnologico del Sistema de I + D + i y del Programa Estatal de I + D + i Orientada a los Retos de la Sociedad, del Plan Estatal de Investigacion Cientifica y Tecnica y de Innovacion (PID2020-115499RB-I00/AEI/10.130 39/501100011033). Programa Estatal de I + D + I orientada a los Retos de la Sociedad (BFU 2016-75038-R), financed by the Agencia Estatal de Investigacion (AEI) and the Fondo Europeo de Desarrollo Regional (FEDER), Ministerio de Economia y Competitividad. Proyectos de I + D + i, en regimen de concurrencia competitiva, destinadas a las universidades y entidades publicas de investigacion calificadas como agentes del Sistema Andaluz del Conocimiento, en el ambito del Plan Andaluz de Investigacion, Desarrollo e Innovación (PAIDI 2020). Andalucia se mueve con Europa (P20-00928)

Determinación del grado de regeneración hepática ante tres diferentes técnicas de hepatectomía Parcial

After the left hepatic lobectomy the authors compared the liver regeneration by practicing three different techniques: non vascular exclusion, partial vascular éxclusion and total vascular exclusion. Nine pigs separated in three gloups are used as expenmental animals. The results are analysed based on the histopathology (mitotic index) and the hepatic enzyms. The conclusion is that there doesn't exist any difference in the liveer regeneration degfee between the compared techniquesSe determinó el grado de regeneración hepática luego de la lobectomía hepática izquierda. Se compararon los iesultados obtenidos entre tres diferentes técnicas de hepatectomía parcial:sin clampeo vascular hepático, con clampeo vascular parcial y con clampeo vascular total. Como animales de experimentación se utilizaron nueve porcinos divididos en tres grupos de tres animales cada uno. Los resultados se analizaron en base a la histopatología (índice mitótico) y por valoración de enzimas hepáticas. Se concluye que no existe diferencia significativa en el grado de regeneración hepática entre las técnicas comparadas. E1 tiempo de recuperación posoperatorio aumentó en forma proporcional al porcentaje de parénquima hepático extirpad